Gapped 2' modified oligonucleotides
US6146829A · kind A · utility
53Cited by
17References
15Claims
0Family size
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Key dates
| Filing date | Aug 31, 1998 |
| Grant date | Nov 14, 2000 |
| Priority date | — |
| Expiry date | Aug 31, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2525/125
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and sub-sequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.