Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative
US6184236A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 9, 1999 |
| Grant date | Feb 6, 2001 |
| Priority date | — |
| Expiry date | Aug 9, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of treatment of a disease associated with neurodegeneration by administering a therapeutically effective amount of a compound of the general formula ##STR1## wherein PA1 Ar.sup.1 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonamide; PA1 Ar.sup.2 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by lower alkyl or halogen; PA1 X is C, CH, C(OH) or N; PA1 Y is --CH.sub.2 -, CH or O; PA1 Z --CH.sub.2 --, --CH(CH.sub.3)-- or --C(CH.sub.3).sub.2 --; PA1 R.sup.1 is hydrogen, lower alkyl or acetyl; PA1 A is C.dbd.O or --(CHR.sup.2).sub.n --, wherein R.sup.2 is hydrogen, lower alkyl or hydroxy-lower alkyl; PA1 B is --(CH.sub.2).sub.n --, O, --CH(OH)(CH.sub.2).sub.n --, --CH(CH.sub.2 OH)(CH.sub.2).sub.n --, --(CH.sub.2).sub.n CH(OH)-- or --CH(CH.sub.2 OH)--; PA1 - - - may be a bond; and PA1 n is 0-4, PA1 or pharmaceutically acceptable acid addition salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.