Patent · US Expired

Phosphorothioate oligonucleotides having modified internucleoside linkages

US6242589A · kind A · utility

146Cited by

32References

16Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Phillip Dan Cook · Carlsbad, US
Muthiah Manoharan · Carlsbad, US

Key dates

Filing date	Jul 14, 1998
Grant date	Jun 5, 2001
Priority date	—
Expiry date	Jul 14, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are phosphorothioate oligonucleotides wherein the 5'-terminal internucleoside linkage or the 5'- and 3'-terminal linkages are modified.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.