RNA targeted 2'-modified oligonucleotides that are conformationally preorganized
US6271358A · kind A · utility
119Cited by
7References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1998 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Jul 27, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.