Methods of producing immunoglobulins, vectors and transformed host cells for use therein

US6331415A · kind A · utility

Assignee

• Genentech, Inc. · US

Inventors

• Shmuel Cabilly · Gdera, IL
• Herbert L. Heyneker · Hillsborough, US
• William E. Holmes · Pacifica, US
• Arthur D. Riggs · La Verne, US
• Ronald B. Wetzel · San Francisco, US

Key dates

• Filing date: Jun 10, 1988
• Grant date: Dec 18, 2001
• Expiry date: Jun 10, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.