Nucleosidic and non-nucleosidic folate conjugates
US6335434B1 · kind B1 · utility
287Cited by
185References
4Claims
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Key dates
| Filing date | Mar 24, 1999 |
| Grant date | Jan 1, 2002 |
| Priority date | — |
| Expiry date | Mar 24, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D475/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the &agr;- or &ggr;-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are diclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.