4-hydroxy-piperidine derivatives
US6359138B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 24, 1997 |
| Grant date | Mar 19, 2002 |
| Priority date | — |
| Expiry date | Nov 24, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to 4-hydroxy-piperidine derivatives of the general formula whereinX denotes —O—, —NH—, —CH2—, —CH═, —CHOH—, —CO—, —S—, —SO— or —SO2—;R1-R4 are, independently from each other, hydrogen, hydroxy, lower-alkyl-sulfonylamino, 1- or 2-imidazolyl or acetamido;R5-R8 are, independently from each other, hydrogen, hydroxy, lower-alkyl, halogen, lower-alkoxy, trifluoromethyl or trifluoromethyloxy;a and b may be a double bond, provided that when “a” is a double bond, “b” cannot be a double bond;n is 0-2;m is 1-3;p is 0 or 1and to pharmaceutically acceptable addition salts thereof.Compounds of the present invention are NMDA(N-methyl-D-aspartate)-receptor subtype selective blockers, which can be used in mediating processes underlying development of CNS including learning and memory formation and function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.