Arylysulphonamide-substituted benzimidazoles having tryptase-inhibiting activity

US6365584B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Christine Braun · Giubiasco, CH
• Hans Briem · Bremen, DE
• Bernd Disse · Ingelheim am Rhein, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Hans Michael Jennewein · Wiesbaden, DE
• Georg Speck · Ingelheim am Rhein, DE

Key dates

• Filing date: Sep 21, 2000
• Grant date: Apr 2, 2002
• Expiry date: Sep 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Arylsulphonamide-substituted benzimidazole derivatives of formula (I) having tryptase-inhibiting activity. Exemplary are:1-Methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(2-diethylaminoethyl)-benzenesulphonylamino]-benzimidazole;1-Methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(2-diethlylaminoethyl)-benzylsulfonylamino]-benzimidazole; and,1-Methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(3-diethylaminopropyl)-benzenesulphonylamino]-benzimidazole.