Epothilone analogs
US6380394B1 · kind B1 · utility
54Cited by
0References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1998 |
| Grant date | Apr 30, 2002 |
| Priority date | — |
| Expiry date | Jun 22, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel analogs of epothilone A, epothilone B, and epothilone C are synthesized by Stille coupling thazole-stannanes to macrolactone intermediates. The synthetic epothilone analogs selectively prevent mitosis in cancer cells through the induction and stabilization of microtubulin assembly. Selected synthetic epothilone analogs are demonstrated to have greater bioactivity than their corresponding native compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.