Structure, production and use of heregulin 2 ligands
US6399746B1 · kind B1 · utility
18Cited by
1References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 14, 1998 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Oct 14, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-&agr; and heregulin 2-&bgr;, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-&agr; has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-&agr; useful in the production of heregulin 2-&agr; by recombinant means. Further provided an amino acid sequence of heregulin 2-&agr; and heregulin 2-&bgr;. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.