Carboxamide-substituted benzimidazoles having tryptase-inhibiting activity

US6407130B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Christine Braun · Giubiasco, CH
• Hans Briem · Bremen, DE
• Bernd Disse · Ingelheim am Rhein, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Hans Michael Jennewein · Wiesbaden, DE
• Georg Speck · Ingelheim am Rhein, DE

Key dates

• Filing date: Nov 2, 2000
• Grant date: Jun 18, 2002
• Expiry date: Nov 2, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to carboxamide-substituted benzimidazole derivatives of general formula (I) wherein the groups R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for preparing them and the use of carboxamide-substituted benzimidazole derivatives as pharmaceutical compositions, particularly as pharmaceutical compositions with a tryptase-inhibiting effect.