Arylsulphonamide-substituted benzimidazoles having tryptase-inhibiting activity

US6413990B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Christine Braun · Giubiasco, CH
• Hans Briem · Bremen, DE
• Bernd Disse · Ingelheim am Rhein, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Hans Michael Jennewein · Wiesbaden, DE
• Georg Speck · Ingelheim am Rhein, DE

Key dates

• Filing date: Sep 21, 2000
• Grant date: Jul 2, 2002
• Expiry date: Sep 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bezimidazole derivatives of general formula (I) having tryptase-inhibitory activity. Exemplary are:N-{2-[2-(4-amidinophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-diethylaminoethyl-(4-ethoxycarbonyl-benzenesulphonamide)-hydrochloride,N-{2-[2-(4-amidinophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-diethylaminoethyl-(dansylamide)-dihydrochloride, andN-{2-[2-(4-amidinophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-diethylaminoethyl-(3-bromo-benzenesulphonamide)-hydrochloride.