Patent · US Expired

Oligonucleotide analogs having modified dimers

US6420549B1 · kind B1 · utility

43Cited by

159References

21Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Phillip Dan Cook · Carlsbad, US
Muthiah Manoharan · Carlsbad, US
Balkrishen Bhat · Carlsbad, US

Key dates

Filing date	Aug 7, 1998
Grant date	Jul 16, 2002
Priority date	—
Expiry date	Oct 2, 2018

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/582
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.