Linked peptide nucleic acids
US6441130B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 28, 1998 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Jun 28, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3513
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.