Heterocyclic compounds useful as NMDA receptor selective subtype blockers
US6451819B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 2001 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Apr 12, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to treating neurodegeneration by selective blocking of NMDA receptor with compounds of formula whereinAr1 is pyridyl or phenyl, substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or is the group  whereinZ1 is a five membered heterocyclic ring, which contains one or two heteroatoms, selected from N or O;R1 is hydrogen, hydroxy or an oxo group;Ar2 is pyridyl or phenyl, optionally substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or is the group  whereinZ2 is a five or six membered ring, which optionally contains one or two heteroatoms, selected from N or O; andQ, X, A, Y B are as defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.