Sugar-modified gapped oligonucleotides
US6451991B1 · kind B1 · utility
228Cited by
9References
14Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 11, 1997 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Feb 11, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotides are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary nucleic acid strand, and subsequences of 2′-deoxy-erythro-pentofuranosyl nucleosides that activate RNase H. Such oligonucleotides are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to ooligonucleotide therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.