Pyrrolidine modulators of chemokine receptor activity

US6498161B1 · kind B1 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Charles G. Caldwell · Dallas, US
• Kevin T. Chapman · Emeryville, US
• Jeffrey J. Hale · Westfield, US
• Dooseop Kim · Scotch Plains, US
• Christopher L. Lynch · Pleasant Prairie, US
• Malcolm MacCoss · Freehold, US
• Sander G. Mills · Scotch Plains, US
• Christopher Willoughby · Somerville, US
• Scott Berk · Cambridge, US
• Ronald Kim · Essen, DE

Key dates

• Filing date: Apr 4, 2000
• Grant date: Dec 24, 2002
• Expiry date: Apr 4, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.