Pyrazole compositions useful as inhibitors of ERK

US6528509B1 · kind B1 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Michael Hale · Bedford, US
• Xiaoling Xie · Cambridge, US
• Jeremy Green · Waltham, US
• Jingrong Cao · Newton, US
• Christopher Baker · Bedford, US
• Francois Maltais · Somerville, US
• James Janetka · Beverly, US
• Guy Bemis · Arlington, US
• Michael D. Mullican · Needham, US
• Judith Straub · Cambridge, US
• Qing Tang · Acton, US
• Robert Mashal · Newton, US

Key dates

• Filing date: Oct 5, 2001
• Grant date: Mar 4, 2003
• Expiry date: Oct 5, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.