Pyrrolidine derivatives

US6541638B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Johannes Aebi · Binningen, CH
• Denise Blum · Basel, CH
• Daniel Bur · Therwil, CH
• Alexander Chucholowski · San Diego, US
• Henrietta Dehmlow · Weil am Rhein, DE
• Eric A. Kitas · Aesch, CH
• Bernd Loeffler · Oberrimsingen, DE
• Ulrike Obst · Weil am Rhein, DE
• Sabine Wallbaum · Esslingen am Neckar, DE

Key dates

• Filing date: Jul 17, 2001
• Grant date: Apr 1, 2003
• Expiry date: Jul 17, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.