2′-O-aminoethyloxyethyl-modified oligonucleotides
US6600032B1 · kind B1 · utility
184Cited by
32References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 6, 1999 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Aug 6, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/341
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
2′-O-Modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed. Oligomeric compounds are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2′-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3′ endo geometries.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.