Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
US6652855B1 · kind B1 · utility
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9Claims
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Key dates
| Filing date | Feb 11, 2002 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Feb 11, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need therof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.