Efficient and selective adenoviral-mediated gene transfer into vascular neointima
US6682728B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1993 |
| Grant date | Jan 27, 2004 |
| Priority date | — |
| Expiry date | Oct 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10343
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of selectively expressing DNA in neointimal cells in an injured blood vessel of a subject comprising administering a replication-deficient recombinant adenovirus which functionally encodes the DNA to the blood vessel at the site of injury, such that the adenovirus remains at the site of injury for a time sufficient for the adenovirus to selectively infect neointimal cells and thereby selectively express the DNA in neointimal cells. In particular, the invention provides administering a replication-deficient recombinant adenovirus which functionally encodes a DNA encoding a protein or an antisense ribonucleic acid. This method can be used to treat restenosis and, relatedly, prevent neointimal cell proliferation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.