Inhibitors of c-JUN N terminal kinases (JNK) and other protein kinases

US6693108B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Jeremy Green · Waltham, US
• Guy Bemis · Arlington, US
• Anne-Laure Grillot · Cambridge, US
• Mark Ledeboer · Acton, US
• Francesco G. Salituro · Marlborough, US
• Edmund Harrington · Plymouth, US
• Huai Gao · Arlington, US
• Christopher Baker · Bedford, US
• Jingrong Cao · Newton, US
• Michael Hale · Bedford, US

Key dates

• Filing date: Feb 12, 2002
• Grant date: Feb 17, 2004
• Expiry date: Feb 12, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.