Dihydroindole and tetrahydroquinoline derivatives

US6706751B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Johannes Aebi · Binningen, CH
• Jean Ackermann · Riehen, CH
• Alexander Chucholowski · San Diego, US
• Henrietta Dehmlow · Weil am Rhein, DE
• Olivier Morand · Hégenheim, FR
• Sabine Wallbaum · Esslingen am Neckar, DE
• Thomas Weller · Binningen, CH
• Narendra Panday · Basel, CH

Key dates

• Filing date: Dec 11, 2001
• Grant date: Mar 16, 2004
• Expiry date: Dec 11, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.