2,3-oxidosqualene-lanosterol cyclase inhibitors

US6858651B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Jean Ackermann · Riehen, CH
• Johannes Aebi · Binningen, CH
• Denise Blum · Basel, CH
• Alexander Chucholowski · San Diego, US
• Henrietta Dehmlow · Weil am Rhein, DE
• Hans-Peter Maerki · Basel, CH
• Olivier Morand · Hégenheim, FR
• Rene Trussardi · Basel, CH
• Elisabeth von der Mark · Bad Bellingen, DE
• Sabine Wallbaum · Esslingen am Neckar, DE
• Thomas Weller · Binningen, CH

Key dates

• Filing date: Aug 9, 2001
• Grant date: Feb 22, 2005
• Expiry date: Sep 30, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.