Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
US6867294B1 · kind B1 · utility
158Cited by
145References
11Claims
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Key dates
| Filing date | Nov 12, 1999 |
| Grant date | Mar 15, 2005 |
| Priority date | — |
| Expiry date | Nov 12, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.