Antibodies to heregulin 2
US6953842B2 · kind B2 · utility
4Cited by
11References
7Claims
0Family size
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Key dates
| Filing date | Dec 17, 2001 |
| Grant date | Oct 11, 2005 |
| Priority date | — |
| Expiry date | Dec 17, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 2 polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-α and heregulin 2-β, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-α has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-α useful in the production of heregulin 2-α by recombinant means. Further provided an amino acid sequence of heregulin 2-α and heregulin 2-β. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.