ITI-D1 Kunitz domain mutants as HNE inhibitors
US7078383B2 · kind B2 · utility
21Cited by
8References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 8, 2002 |
| Grant date | Jul 18, 2006 |
| Priority date | — |
| Expiry date | Aug 29, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2795/14111
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.