Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor

US7157495B2 · kind B2 · utility

Assignees

• Tibotec Pharmaceuticals Ltd. · IE
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Guangyang Wang · 安丰镇, CN
• Michael Eissenstat · Frederick, US
• John W. Erickson · Barrington, US
• Piet Tom Bert Paul Wigerinck · Terhagen, BE

Key dates

• Filing date: Jun 25, 2003
• Grant date: Jan 2, 2007
• Expiry date: Oct 13, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions comprising bis-tetrahydrofuran benzodioxyolyl sulfonamide compounds that are surprisingly effective protease inhibitors and a second antiretroviral compound are disclosed. Methods of inhibiting retrovirus proteases, in particular multi-drug resistant retrovirus proteases, methods of treating or preventing infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication are also disclosed.