Epothilone analogs
US7173137B2 · kind B2 · utility
3Cited by
16References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 9, 2003 |
| Grant date | Feb 6, 2007 |
| Priority date | — |
| Expiry date | Jun 22, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the analogs are demonstrated to have a superior cytotoxic activity as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.