Heterocyclic inhibitors of ERK2 and uses thereof
US7253187B2 · kind B2 · utility
69Cited by
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25Claims
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Key dates
| Filing date | Feb 3, 2004 |
| Grant date | Aug 7, 2007 |
| Priority date | — |
| Expiry date | Aug 5, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compounds that are useful as protein kinase inhibitors having the formula:wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.