Protein kinase inhibitors and uses thereof

US7304071B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• John Cochran · North Andover, US
• Jeremy Green · Waltham, US
• Michael Hale · Bedford, US
• Brian Ledford · Attleboro, US
• Francois Maltais · Somerville, US
• Suganthini S. Nanthakumar · Newton, US

Key dates

• Filing date: Aug 12, 2003
• Grant date: Dec 4, 2007
• Expiry date: Jul 22, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V:or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, T, m, n, p, Q, Q′, R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.