Cyclopropyl and cyclobutyl epothilone analogs
US7358266B2 · kind B2 · utility
2Cited by
5References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2002 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Nov 27, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IVwherein Ar is a radical represented by the following structure:and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.