Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
US7626014B2 · kind B2 · utility
22Cited by
27References
64Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 27, 2005 |
| Grant date | Dec 1, 2009 |
| Priority date | — |
| Expiry date | Oct 23, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improves the pharmacokinetic properties of the oligonucleotides. The aralkyl ligands of the present invention include naproxen, ibuprofen and derivatives thereof. The present invention also provides methods for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.