Patent · US Active

Benzimidazole derivatives

US7645785B2 · kind B2 · utility

1Cited by

0References

65Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Gregory Martin Benson · Therwil, CH
Konrad Bleicher · Glückstadt, DE
Alexander Chucholowski · San Diego, US
Henrietta Dehmlow · Weil am Rhein, DE
Uwe Grether · Weil am Rhein, DE
Bernd Kuhn · Sursee, CH
Rainer E. Martin · Basel, CH
Eric Niesor · Gland, CH
Narendra Panday · Basel, CH
Hans Richter · Weil am Rhein, DE
Franz Schuler · Riehen, CH
Xavier Marie Warot · Strasbourg, FR
Matthew Wright · Basel, CH
Minmin Yang · Nanjing, CN

Key dates

Filing date	Jun 22, 2007
Grant date	Jan 12, 2010
Priority date	—
Expiry date	Jun 22, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention is concerned with novel benzimidazole derivatives of formula (I)wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.