Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

US7705148B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Didier Schils · Loupoigne, BE
• Joannes Josephus Maria Willems · Oud-Turnhout, BE
• Bart Petrus Anna Maria Jozef Medaer · Lille, BE
• Elisabeth Therese Jeanne Pasquier · Le Neubourg, FR
• Paul Adriaan Jan Janssen · Vosselaar, BE
• Jan Heeres · Vosselaar, BE
• Ruben Gerardus George Leenders · Nijmegen, NL
• Jérôme Emile Georges Guillemont · Andé, FR

Key dates

• Filing date: Feb 14, 2008
• Grant date: Apr 27, 2010
• Expiry date: Feb 14, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C253/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: in the presence of a suitable solvent; with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent;