Methods for preparing Bacillus anthracis protective antigen for use in vaccines

US7763451B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Joseph Shiloach · Rockville, US
• Stephen H. Leppla · Bethesda, US
• Delia M. Ramirez · Bethesda, US
• Rachel Schneerson · Bethesda, US
• John B. Robbins · New York, US
• S. Dana Hsu · Bethesda, US
• Mary Jo Rosovitz · Germantown, US

Key dates

• Filing date: Nov 8, 2002
• Grant date: Jul 27, 2010
• Expiry date: Jan 9, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.