Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli

US7803386B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Rachel Schneerson · Bethesda, US
• Stephen H. Leppla · Bethesda, US
• John B. Robbins · New York, US
• Joseph Shiloach · Rockville, US
• Joanna Kubler-Kielb · Rockville, US
• Darrell T. Liu · Bethesda, US
• Fathy Majadly · Frederick, US

Key dates

• Filing date: Jun 4, 2004
• Grant date: Sep 28, 2010
• Expiry date: Jun 4, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/627
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus that expresses a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.