Delivery of proteins across polar epithelial cell layers

US7824695B1 · kind B1 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• Genentech, Inc. · US

Inventors

• David Fitzgerald · Rockville, US
• Randall J. Mrsny · Los Altos Hills, US
• Marian L. McKee · Great Falls, US
• Ann Daugherty · Palo Alto, US

Key dates

• Filing date: Oct 18, 2000
• Grant date: Nov 2, 2010
• Expiry date: Jan 27, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to α2 macroglobulin receptor α2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.