Attenuated parainfluenza virus (PIV) vaccines

US7951383B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Brian R. Murphy · Bethesda, US
• Peter L. Collins · Kensington, US
• Mario H. Skiadopoulos · Potomac, US

Key dates

• Filing date: Apr 17, 2007
• Grant date: May 31, 2011
• Expiry date: Nov 14, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2810/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant viruses in vitro. The invention also provides recombinant Human Parainfluenza viruses having one or more mutations that attenuate replication of the virus in a host.