Chromosome 3p21.3 genes are tumor suppressors

US7977468B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Lin Ji · Sugar Land, US
• John Minna · Dallas, US
• Jack A. Roth · Houston, US
• Michael Lerman · Rockville, US

Key dates

• Filing date: Oct 31, 2007
• Grant date: Jul 12, 2011
• Expiry date: Nov 18, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/916
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.