Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
US7999107B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 2008 |
| Grant date | Aug 16, 2011 |
| Priority date | — |
| Expiry date | Feb 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.