Patent · US Active

Mutant DNA polymerases with improved pyrophosphorolysis activated polymerization (PAP) ability

US8071536B2 · kind B2 · utility

2Cited by

4References

22Claims

0Family size

Assignee

Roche Molecular Systems, Inc. · US

Inventors

Keith Bauer · Los Altos, US
David H. Gelfand · Oakland, US

Key dates

Filing date	Nov 26, 2008
Grant date	Dec 6, 2011
Priority date	—
Expiry date	Jun 29, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/1252
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.