Patent · US Active

Compositions and methods for delivering RNAI using lipoproteins

US8324366B2 · kind B2 · utility

3Cited by

70References

18Claims

0Family size

Assignees

Alnylam Pharmaceuticals, Inc. · US
ETH ZURICH · CH

Inventors

Akin Akinc · Cambridge, US
Tomoko Nakayama · Cambridge, US
Muthiah Manoharan · Carlsbad, US
Markus Stoffel · Herrliberg, CH

Key dates

Filing date	Apr 29, 2009
Grant date	Dec 4, 2012
Priority date	—
Expiry date	Jun 2, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates to new compositions comprising at least one of a single or double stranded oligonucleotide, where said oligonucleotide has been conjugated to a lipophile and to which the conjugated oligonucleotide has been preassembled with lipoproteins. These compositions are effectively in delivering oligonucleotides to mammalian tissue where they effect gene silencing.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.