Multimeric protein toxins to target cells having multiple identifying characteristics

US8388933B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Stephen H. Leppla · Bethesda, US
• Shi-Hui Liu · Bethesda, US
• Thomas Bugge · Bethesda, US

Key dates

• Filing date: Apr 15, 2011
• Grant date: Mar 5, 2013
• Expiry date: Apr 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases.