Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
US8470988B2 · kind B2 · utility
3Cited by
27References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 23, 2009 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Oct 30, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improvise the pharmacokinetic properties of the oligonucleotide. The aralkyl ligands of the present invention include naproxen, ibuprofen, and derivatives thereof. The present invention also provides method for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.