Chemically modified oligonucleotides for use in modulation micro RNA and uses thereof
US8541385B2 · kind B2 · utility
17Cited by
10References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 1, 2010 |
| Grant date | Sep 24, 2013 |
| Priority date | — |
| Expiry date | Feb 8, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3533
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates generally to chemically modified oligonuceotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonuceotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides. Also included in the invention are compositions and methods for silencing microRNAs in the central nervous system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.