Substituted triazolopyridines

US8551980B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Volker Schulze · Hohen Neuendorf, DE
• Marcus Koppitz · Berlin, DE
• Dirk Kosemund · Berlin, DE
• Benjamin Bader · Berlin, DE
• Philip Lienau · Berlin, DE
• Hans Briem · Bremen, DE
• Simon Holton · Berlin, DE
• Gerhard Siemeister · Berlin, DE
• Stefan Prechtl · Berlin, DE
• Antje Margret Wengner · Berlin, DE

Key dates

• Filing date: Nov 17, 2010
• Grant date: Oct 8, 2013
• Expiry date: Nov 17, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.