Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

US8598343B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Shen-Chun Kuo · Union, US
• Yonggang Chen · Nanhu, CN
• Jeffrey Eckert · Hazlet, US
• William W. Leong · Westfield, US
• Nanfei Zou · Fanwood, US
• Gabriel Christian Kuklis · Huntsville, US

Key dates

• Filing date: Aug 3, 2010
• Grant date: Dec 3, 2013
• Expiry date: Aug 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, intermediates useful in that process, and processes for preparing said intermediates are disclosed.