Furopyridinyl-substituted 1,4-dihydropyridine derivatives and methods of use thereof

US8604028B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Martin Michels
• Hans Briem · Bremen, DE
• Alexandros Vakalopoulos · Hilden, DE
• Katja Zimmermann · Mülheim an der Ruhr, DE
• Nicole Teusch · Uerdingen, DE

Key dates

• Filing date: Nov 15, 2010
• Grant date: Dec 10, 2013
• Expiry date: Nov 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel 4-(furo[3,2-c]pyridin-2-yl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.